Amplicon Sequencing Service for microbial community characterisation from environmental and human samples

Finnish Institute for Health and Welfare

In the context of multiple national and international projects or other assignments, Institute for Health and Welfare (THL) has collected samples from natural and man-made environments (indoor air, dust, water, etc.), as well as from humans (skin swabs, nasal swabs, throat swabs, etc.), and future efforts will involve additional sample collections, sample processing and extraction and purification of genomic DNA from those samples. In addition, from part of the samples, also total RNA has been or will be extracted. The objective of the procurement is to generate amplicon sequencing data from the collected samples. The microbiome targets include primarily bacteria/archaea (16S rRNA), microeukaryotes (18S rRNA) and fungi (ITS sequence) but may also include other targets eg. viruses, protozoa, or functional genes. Amplicon sequencing service (complete service from nucleic acids): THL will ship the nucleic acids (DNA and/or cDNA samples) to be sequenced, typically in 15-50 μl volume, to the service provider. The samples are non-infectious, purified DNA, closed in screw-capped tubes or sealed in a 96-well plate. The samples will be shipped in multiple batches of different sizes. A typical batch size will be 100 to 500 samples, but batches may be also smaller or larger on occasion. The service to be provided includes PCR amplification of the target region of interest (16S rRNA, ITS, 18S rRNA, etc.) and subsequent amplicon sequencing on Illumina MiSeq V3 or comparable platforms, to generate sequences with a target size of 300bp or more. We expect the service provider to store the remainder of the sample batch for possible later sequencing up to one year and/or communicate with THL returning unused nucleic acids. We expect to be able to discuss in detail PCR and sequencing conditions for each batch to be processed before the start of each sequencing project. The contract will be awarded to one (1) Service Provider based on a comparison of tenders. Tender that is economically the most advantageous will win the competition. The most economically advantageous Tender shall be a Tender with lowest price. The estimated start time for the contract is autumn 2024. The contract period is valid for two (2) years and thereafter until further notice.

Määräaika

Tarjousten vastaanottamisen määräaika oli 2024-05-27. Hankinta julkaistiin 2024-04-24.

Kuka?

• Finnish Institute for Health and Welfare

Mitä?

• Tutkimuspalvelut › Tutkimuslaboratorioiden palvelut

Missä?

• Helsinki-Uusimaa › Helsinki-Uusimaa
• Pohjois- ja Itä-Suomi › Pohjois-Savo

Hankintojen historia

Päivämäärä	Asiakirja
2024-04-24	hankintailmoitus

hankintailmoitus (2024-04-24)
Kohde
Hankinnan laajuus
Otsikko: Amplicon Sequencing Service for microbial community characterisation from environmental and human samples
Viitenumero: THL/1208/2.02.06/2023
Lyhyt kuvaus:

Lyhyt kuvaus

In the context of multiple national and international projects or other assignments, Institute for Health and Welfare (THL) has collected samples from natural and man-made environments (indoor air, dust, water, etc.), as well as from humans (skin swabs, nasal swabs, throat swabs, etc.), and future efforts will involve additional sample collections, sample processing and extraction and purification of genomic DNA from those samples. In addition, from part of the samples, also total RNA has been or will be extracted. The objective of the procurement is to generate amplicon sequencing data from the collected samples. The microbiome targets include primarily bacteria/archaea (16S rRNA), microeukaryotes (18S rRNA) and fungi (ITS sequence) but may also include other targets eg. viruses, protozoa, or functional genes.

Amplicon sequencing service (complete service from nucleic acids): THL will ship the nucleic acids (DNA and/or cDNA samples) to be sequenced, typically in 15-50 μl volume, to the service provider. The samples are non-infectious, purified DNA, closed in screw-capped tubes or sealed in a 96-well plate. The samples will be shipped in multiple batches of different sizes. A typical batch size will be 100 to 500 samples, but batches may be also smaller or larger on occasion. The service to be provided includes PCR amplification of the target region of interest (16S rRNA, ITS, 18S rRNA, etc.) and subsequent amplicon sequencing on Illumina MiSeq V3 or comparable platforms, to generate sequences with a target size of 300bp or more. We expect the service provider to store the remainder of the sample batch for possible later sequencing up to one year and/or communicate with THL returning unused nucleic acids. We expect to be able to discuss in detail PCR and sequencing conditions for each batch to be processed before the start of each sequencing project.

The contract will be awarded to one (1) Service Provider based on a comparison of tenders. Tender that is economically the most advantageous will win the competition. The most economically advantageous Tender shall be a Tender with lowest price.

The estimated start time for the contract is autumn 2024.

The contract period is valid for two (2) years and thereafter until further notice.

Sopimustyyppi: Palvelut
Tuotteet/palvelut: Tutkimuslaboratorioiden palvelut 📦
Kuvaus
Sisäinen tunniste: 697950
Tämä hankinta soveltuu myös pienille ja keskisuurille yrityksille (pk-yrityksille) ✅
Lisätietoja:

The main place for the service is Kuopio, but it is possible to be Helsinki also.

Postiosoite: Neulaniementie 4
Postinumero: 70210
Postitoimipaikka: Kuopio
Postiosoite: Mannerheimintie 166
Postinumero: 00270
Postitoimipaikka: Helsinki
Maa: Suomi 🇫🇮
Suorituspaikka:

Helsinki-Uusimaa 🏙️

Pohjois-Savo 🏙️

Kesto: 48 kuukautta
Tietoa vaihtoehdoista
Vaihtoehdot ✅
Vaihtoehtojen kuvaus:

The contract is valid for two (2) years and after that it is valid until further notice.

Myöntämisperusteet
Hinta ✅
Otsikko
Erän tunnistenumero: LOT-0000

Menettely
Toimenpiteen tyyppi
Avoin menettely ✅
Oikeusperusta: Direktiivi 2014/24/EU
Menettelyn tärkeimmät piirteet:

An open procedure is applied. The contract will be awarded through an open procedure and is subject to Finland's Act on Public Procurement and Concession Contracts (1397/2016) and the Directive 2014/24/EU on public procurement. The contract value is estimated to exceed the EU threshold value. Tenders must be submitted electronically on the Cloudia Supplier Portal. It is the responsibility of the Tenderer to submit the tender by deadline. No compensation will be paid for submitting a tender. Requirements concerning the tenderers and the service are described in this Call for Tenders. All the attachments mentioned in the Call for Tenders should be sent with the tender. The tender must be submitted in English. Also, the annexes and all related material or correspondence must be in English. Please note that all times given in the Call for Tender refer to local time in Finland. The process steps are: 1. Opening the tenders. 2. Inspecting the suitability of the Tenderers according to the ESPD form. 3. Inspecting that the tenders meet the requirements set in the Call for Tender. 4. Comparison of tenders. 5. Making and announcing the contract decision. 7. Verifying the information given by the awarded tenderer on the ESPD form. 8. Background check by asking the awarded tenderer to submit criminal record extracts. 9. Finalization of the procurement contract. The procurement contract only enters into force when both parties have signed it. The procurement contract can be signed no earlier than 14 days from the time the tenderer has been informed, or is considered to have been informed, of the contract decision and its grounds (=stand-still period).

Menettelyn tärkeimmät piirteet

An open procedure is applied. The contract will be awarded through an open procedure and is subject to Finland's Act on Public Procurement and Concession Contracts (1397/2016) and the Directive 2014/24/EU on public procurement. The contract value is estimated to exceed the EU threshold value.

Tenders must be submitted electronically on the Cloudia Supplier Portal. It is the responsibility of the Tenderer to submit the tender by deadline. No compensation will be paid for submitting a tender. Requirements concerning the tenderers and the service are described in this Call for Tenders.

All the attachments mentioned in the Call for Tenders should be sent with the tender. The tender must be submitted in English. Also, the annexes and all related material or correspondence must be in English. Please note that all times given in the Call for Tender refer to local time in Finland.

The process steps are:

1. Opening the tenders.
2. Inspecting the suitability of the Tenderers according to the ESPD form.
3. Inspecting that the tenders meet the requirements set in the Call for Tender.
4. Comparison of tenders.
5. Making and announcing the contract decision.
7. Verifying the information given by the awarded tenderer on the ESPD form.
8. Background check by asking the awarded tenderer to submit criminal record extracts.
9. Finalization of the procurement contract. The procurement contract only enters into force when both parties have signed it.

The procurement contract can be signed no earlier than 14 days from the time the tenderer has been informed, or is considered to have been informed, of the contract decision and its grounds (=stand-still period).

Hallinnolliset tiedot
Tarjousten tai osallistumishakemusten vastaanottamisen määräaika: 2024-05-27 09:00:00 📅
Tarjousten avaamista koskevat ehdot: 2024-05-27 09:01:00 📅
Kielet, joilla tarjoukset tai osallistumishakemukset voidaan jättää: englanti 🗣️
Vähimmäisaika, jonka kuluessa tarjoajan on pidettävä tarjous voimassa: 6 kuukautta
Tarjouspyynnön ehdot
Tarjoaja voi jättää useamman kuin yhden tarjouksen
Tarjousten avaamisen päivämäärä: 2024-05-27 09:01:00 📅
Sähköinen laskutus: Pakollinen
Sähköistä tilaamista käytetään ✅
Sähköistä maksua käytetään ✅
Lisätietojen pyytämisen määräaika: 2024-05-10 13:00:00 📅

Oikeudelliset, taloudelliset, rahoitukselliset ja tekniset tiedot
Taloudellinen ja rahoituksellinen asema
Luettelo ja lyhyt kuvaus valintaperusteista:

The tenderer's financial prerequisites are sufficient with regard to the size and nature of the procurement.

Tekninen ja ammatillinen pätevyys

The tenderer shall have documented experience with low-density DNA samples, such as indoor air or drinking-water. The tenderer shall provide reference to at least two (2) scientific publications or reports to a similar, low-DNA environmental sample project sequenced by the tenderer.

Osallistumisehdot
Poissulkemisperuste:

Ennenaikainen irtisanominen, vahingonkorvaukset tai muut vastaavat seuraamukset

Järjestelyt velkojien kanssa

Kansallisesta lainsäädännöstä johtuva konkurssia tai muuta sellaista vastaava tilanne

+ 21 lisää

Konkurssi

Korruptio

Lapsityövoima ja muut ihmiskaupan muodot

Liiketoiminta on keskeytetty

Maksukyvyttömyys

Petos

Puhtaasti kansalliset poissulkemisperusteet

Rahanpesu tai terrorismin rahoitus

Rikollisjärjestön toimintaan osallistuminen

Sosiaalilainsäädännön mukaisten velvoitteiden rikkominen

Sosiaaliturvamaksujen maksaminen

Syyllistyminen ammatin harjoittamiseen liittyvään vakavaan virheeseen

Syyllistyminen väärien tietojen antamiseen, tietojen antamatta jättämiseen, vaadittujen asiakirjojen antamiseen kykenemättömien tietojen toimittamiseen ja tätä menettelyä koskevien luottamuksellisten tietojen antamiseen

Talouden toimijan hankintamenettelyyn osallistumisesta johtuvat eturistiriidat

Terrorismirikokset tai terroritoimintaan liittyvät rikokset

Toisten talouden toimijoiden kanssa kilpailun vääristämiseksi tehdyt sopimukset

Työlainsäädännön mukaisten velvoitteiden rikkominen

Varat selvitysmiehen hallinnassa

Verojen maksu

Välitön tai välillinen osallistuminen tämän hankintamenettelyn valmisteluun

Ympäristölainsäädännön mukaisten velvoitteiden rikkominen

Kuvaus poissulkemisperusteista:

The economic operator is in any analogous situation like bankruptcy arising from a similar procedure under national laws and regulations.

The economic operator is bankrupt.

The economic operator itself or any person who is a member of its administrative, management or supervisory body or has powers of representation, decision or control therein has been the subject of a conviction by final judgment for corruption, by a conviction rendered at the most five years ago or in which an exclusion period set out directly in the conviction continues to be applicable.

The economic operator is in arrangement with creditors.

The economic operator itself or any person who is a member of its administrative, management or supervisory body or has powers of representation, decision or control therein has been the subject of a conviction by final judgment for participation in a criminal organisation, by a conviction rendered at the most five years ago or in which an exclusion period set out directly in the conviction continues to be applicable.

The economic operator has entered into agreements with other economic operators aimed at distorting competition.

The economic operator has breached its obligations in the field of environmental law.

… money laundering or terrorist financing, by a conviction rendered at the most five years ago or in which an exclusion period set out directly in the conviction continues to be applicable.

… fraud, by a conviction rendered at the most five years ago or in which an exclusion period set out directly in the conviction continues to be applicable.

… child labour and other forms of trafficking in human beings, by a conviction rendered at the most five years ago or in which an exclusion period set out directly in the conviction continues to be applicable.

The economic operator is the subject of insolvency or winding-up.

The economic operator has breached its obligations in the field of labour law.

The assets of the economic operator are being administered by a liquidator or by the court.

The economic operator can confirm that: a) It has been guilty of serious misrepresentation in supplying the information required for the verification of the absence of grounds for exclusion or the fulfilment of the selection criteria, b) It has withheld such information, c) It has not been able, without delay, to submit the supporting documents required by a contracting authority or contracting entity, and d) It has undertaken to unduly influence the decision making process of the contracting authority or contracting entity, to obtain confidential information that may confer upon it undue advantages in the procurement procedure or to negligently provide misleading information that may have a material influence on decisions concerning exclusion, selection or award.

Any person who is a member of the economic operator’s administrative, management or supervisory body or has powers of representation, decision or control therein has been the subject of a conviction by final judgment for work safety offence, working hours offence, work discrimination, extortionate work discrimination, violation of the right to organise or unauthorised use of foreign labour.

The economic operator is aware of any conflict of interest, as indicated in national law, the relevant notice or the procurement documents due to its participation in the procurement procedure.

The economic operator or an undertaking related to it has advised the contracting authority or contracting entity or otherwise been involved in the preparation of the procurement procedure.

The economic operator is guilty of grave professional misconduct.

The economic operator has experienced that a prior public contract, a prior contract with a contracting entity or a prior concession contract was terminated early, or that damages or other comparable sanctions were imposed in connection with that prior contract.

The economic operator has breached its obligations in the field of social law.

The economic operator has breached its obligations relating to the payment social security contributions, both in the country in which it is established and in Member State of the contracting authority or contracting entity if other than the country of establishment.

The business activities of the economic operator are suspended.

The economic operator has breached its obligations relating to the payment of taxes, both in the country in which it is established and in Member State of the contracting authority or contracting entity if other than the country of establishment.

The economic operator itself or any person who is a member of its administrative, management or supervisory body or has powers of representation, decision or control therein has been the subject of a conviction by final judgment for terrorist offences or offences linked to terrorist activities, by a conviction rendered at the most five years ago or in which an exclusion period set out directly in the conviction continues to be applicable.

Hankintaviranomainen
Nimi ja osoitteet
Nimi: Finnish Institute for Health and Welfare
Kansallinen rekisterinumero: 2229500-6
Postiosoite: PL 30
Postinumero: 00271
Postitoimipaikka: Helsinki
Alue: Helsinki-Uusimaa 🏙️
Maa: Suomi 🇫🇮
Yhteyspiste: Procurement Unit
Sähköposti: kilpailutus@thl.fi 📧
Puhelin: +358 295246000 📞
URL: http://www.thl.fi/ 🌏
Hankintaviranomaisen tyyppi
Julkisoikeudellinen yhteisö
Päätoimi
Terveys
Viestintä
Asiakirjojen URL-osoite: https://tarjouspalvelu.fi/thl?id=492702&tpk=e4c5622d-c477-406e-adfd-2b800b07aa76 🌏
Osallistumisen URL-osoite: https://tarjouspalvelu.fi/thl?id=492702&tpk=e4c5622d-c477-406e-adfd-2b800b07aa76 🌏
Tarjouksen/hakemuksen jättäminen sähköisesti: Pakollinen

Täydentävät tiedot
Lisätietoja

The main place for the service is Kuopio, but it is possible to be Helsinki also.

Arvostelurunko
Nimi: Markkinaoikeus
Kansallinen rekisterinumero: 3006157-6
Postiosoite: Radanrakentajantie 5
Postinumero: 00520
Postitoimipaikka: Helsinki
Alue: Helsinki-Uusimaa 🏙️
Maa: Suomi 🇫🇮
Sähköposti: markkinaoikeus@oikeus.fi 📧
Puhelin: +358 295643300 📞
URL: http://www.oikeus.fi/markkinaoikeus 🌏
Tietoa sähköisistä työnkuluista
Sähköinen laskutus hyväksytään
Lähde: OJS 2024/S 082-247663 (2024-04-24)

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