Ultimate Sensitivity LC-MS/MS System

Helsingin yliopisto

For and on the behalf of the contracting entity University of Helsinki (hereinafter referred to as the Buyer), we invite tenders for
1.1) Ultimate sensitivity LC-MS/MS System for the analysis of lipid mediators, especially the specialized pro-resolving mediators (SPMs) at very low concentration levels, and capable for both ultimate sensitivity MRM quantification and information-dependent acquisition of full MS/MS spectra with high intensity, both from single injection as per enclosed specifications;
1.2) Optional parts for the system (1.1) as per enclosed specifications (II.2.4);
1.3) Training for use and service;
1.3.1) Training on site in connection with the installation;
1.3.2) Additional training for software, setting applications and basic service (option);
1.4) Installation and acceptance test on site;
1.5) Appropriate spare parts for mass spectrometer for 5 years operation.
The acquisition will take place if the funding requested for the acquisition will be granted. Otherwise, the acquisition will be suspended.

Määräaika

Tarjousten vastaanottamisen määräaika oli 2020-11-27. Hankinta julkaistiin 2020-10-27.

Toimittajat

Seuraavat toimittajat mainitaan hankintapäätöksissä tai muissa hankinta-asiakirjoissa:

• A B Sciex Oy

Kuka?

• Helsingin yliopisto

Mitä?

• Spektrometrit › Massaspektrometri

Missä?

• Manner-Suomi › Helsinki-Uusimaa

Hankintojen historia

Päivämäärä	Asiakirja
2020-10-27	hankintailmoitus
2021-01-18	Ilmoitus tehdystä sopimuksesta

hankintailmoitus (2020-10-27)
Kohde
Hankinnan laajuus
Otsikko: Massaspektrometri
Lyhyt kuvaus:

For and on the behalf of the contracting entity University of Helsinki (hereinafter referred to as the Buyer), we invite tenders for 1.1) Ultimate sensitivity LC-MS/MS System for the analysis of lipid mediators, especially the specialized pro-resolving mediators (SPMs) at very low concentration levels, and capable for both ultimate sensitivity MRM quantification and information-dependent acquisition of full MS/MS spectra with high intensity, both from single injection as per enclosed specifications; 1.2) Optional parts for the system (1.1) as per enclosed specifications (II.2.4); 1.3) Training for use and service; 1.3.1) Training on site in connection with the installation; 1.3.2) Additional training for software, setting applications and basic service (option); 1.4) Installation and acceptance test on site; 1.5) Appropriate spare parts for mass spectrometer for 5 years operation. The acquisition will take place if the funding requested for the acquisition will be granted. Otherwise, the acquisition will be suspended.

Ilmoituksen metatiedot
Alkukieli: englanti 🗣️
Asiakirjatyyppi: hankintailmoitus
Sopimuksen luonne: Tavarat
Asetus: Euroopan unioni ja WTO-maat
Yhteinen hankintanimikkeistö (CPV)
Koodi: Massaspektrometri 📦
Suorituspaikka
NUTS-alue: Helsinki-Uusimaa 🏙️

Menettely
Menettelyn tyyppi: Avoin menettely
Tarjouksen tyyppi: Tarjous koskee kaikkia eriä
Myöntämisperusteet
Kokonaistaloudellisesti edullisin tarjous

Hankintaviranomainen
Tunnistetiedot
Maa: Suomi 🇫🇮
Hankintaviranomaisen tyyppi: Julkisoikeudellinen yhteisö
Hankintaviranomaisen nimi: Helsingin yliopisto
Postiosoite: Yliopistonkatu 3
Postinumero: 00014
Postitoimipaikka: Helsinki
Yhteystiedot
Internetosoite: https://www.helsinki.fi/fi 🌏
Sähköposti: katri.e.leino@helsinki.fi 📧
Puhelin: +358 503188076 📞
Asiakirjojen URL-osoite: https://hanki.tarjouspalvelu.fi/hanki?id=316329&tpk=88ac68a4-f594-4253-ae05-c778d6a2e859 🌏
Osallistumisen URL-osoite: https://hanki.tarjouspalvelu.fi/hanki?id=316329&tpk=88ac68a4-f594-4253-ae05-c778d6a2e859 🌏

Viite
Päivämäärät
Lähetyspäivä: 2020-10-27 📅
Tarjousten jättämisen määräaika: 2020-11-27 📅
Julkaisupäivä: 2020-10-30 📅
Tunnisteet
Ilmoituksen numero: 2020/S 212-516056
EUVL-S-numero: 212

Kohde
Hankinnan laajuus
Lyhyt kuvaus:

For and on the behalf of the contracting entity University of Helsinki (hereinafter referred to as the Buyer), we invite tenders for

1.1) Ultimate sensitivity LC-MS/MS System for the analysis of lipid mediators, especially the specialized pro-resolving mediators (SPMs) at very low concentration levels, and capable for both ultimate sensitivity MRM quantification and information-dependent acquisition of full MS/MS spectra with high intensity, both from single injection as per enclosed specifications;

1.2) Optional parts for the system (1.1) as per enclosed specifications (II.2.4);

1.3) Training for use and service;

1.3.1) Training on site in connection with the installation;

1.3.2) Additional training for software, setting applications and basic service (option);

1.4) Installation and acceptance test on site;

1.5) Appropriate spare parts for mass spectrometer for 5 years operation.

The acquisition will take place if the funding requested for the acquisition will be granted. Otherwise, the acquisition will be suspended.

When evaluating offered LC-MS/MS systems, the mass spectrometer performance in the indicated purpose of use (lipid mediator analysis) is the most important criterium. Only new (no demo) equipment can be offered, which applies for all items included.

1) Mass spectrometer requirements are:

(a) Simultaneous

(i) scheduled collection of ultimate sensitivity quantitative MRM (Multiple Reaction Monitoring) data (for lipid mediator quantification); and

(ii) MRM information dependent acquisition of sensitive full scan MS/MS spectral data (with high spectrum intensity, obtained by trapping and concentrating of fragment ions and scanning them out fast, which is required to confidently confirm very low-concentration lipid mediator structures). Thus, in addition to targeted quantitation, the instrument needs to provide structure confirmation of the quantified analytes based on complete high-quality product ion spectra covering the full mass range and from the same one injection and LC-MS/MS acquisition.

(b) Sensitive detection with (lower) limit of quantification (L)LOQ of 0.05 ‒ 1 ng/mL for different lipid mediator species, in general, and with (L)LOQ 0.1 ng/mL or limit of detection (LOD, in matrix) 0.1 pg for the SPMs (resolvins) RvD1 or RvD3, and RvE1 (or lower values). You are requested to attach to your tender as reference three (3) published peer-reviewed research articles confirming that this level of sensitivity has been achieved by researchers for the above-mentioned analytes with the offered MS/MS equipment or older models of the same equipment of the Supplier. By references evidenced ultimate detection sensitivity for the above mentioned resolvins, lower than the (L)LOQ 0.1 ng/mL or LOD (this latter in matrix) 0.1 pg is acknowledged when evaluating quality.

(c) Fast switching between the negative and positive ion mode detection in single injection and one LC-MS/MS acquisition.

These minimum requirements (1a, b, c) rule out triple quadrupole mass spectrometers that do not also have the ion trapping capabilities, required for the ultimate sensitivity SPM detection and high-quality full scan product ion MS/MS spectra. Possibility for true MS3 (i.e. MS/MS/MS) and MRM3 scanning is regarded beneficial when evaluating quality.

2) UHPLC (ultra high pressure liquid chromatograph) system minimum requirements are, that it consists of an autosampler with sample cooling capability, a column oven, a degassing system and a solvent bottle container. The system shall be fully compatible with and fully remotely controllable by the mass spectrometer computer software. Maximum injection volume of the autosampler should be at least 40 μL.

UHPLC quality assessment criteria are listed in other terms and conditions.

Minimum requirements include also (3-6):

3) Computer with adequate processing power and all modern data transfer capabilities. Large monitor and keyboard.

4) One license for the instrument control and data acquisition software and several licenses for the data processing software required for the quantitative and qualitative analyses of the lipid mediators.

5) Transportation to customer’s laboratory and installation therein, including acceptance test on site. The requirements for the site of installation should be specified.

6) Appropriate spare parts.

Following items are quested to be offered as option (7-9):

7) Extended warranty for additional years (extending the standard 24-month warranty of the new LC-MS/MS system) (option).

8) Bench for the LC-MS/MS system (rough pumps inside; soundproofed) (option). Please, specify the dimensions, since laboratory space is limited.

9) Software packages for lipidomics or metabolomics (option).

Kesto: 9 kuukautta
Vaihtoehtojen kuvaus:

Optional parts for the system (1.1) as per enclosed specifications (II.2.4). Additional training for software, setting applications and basic service (option).

Menettely
Oikeusperusta: 32014L0024
Tarjousten vastaanottoaika: 13:00
Kielet, joilla tarjoukset tai osallistumishakemukset voidaan jättää: englanti 🗣️
Tarjouksen voimassaoloaika: 6 kuukautta
Tarjousten avauspäivä: 2020-11-27 📅
Tarjousten avausaika: 13:05

Hankintaviranomainen
Tunnistetiedot
Kansallinen rekisterinumero: 0313471-7
Yhteystiedot
Yhteyspiste: Katri Leino
Asiakirjojen URL-osoite: https://hanki.tarjouspalvelu.fi/hanki?id=316329&tpk=88ac68a4-f594-4253-ae05-c778d6a2e859 🌏

Täydentävät tiedot
Arvostelurunko
Nimi: Markkinaoikeus
Postiosoite: Radanrakentajantie 5
Postitoimipaikka: Helsinki
Postinumero: 00520
Maa: Suomi 🇫🇮
Puhelin: +358 295643300 📞
Sähköposti: markkinaoikeus@oikeus.fi 📧
Internetosoite: http://www.oikeus.fi/markkinaoikeus 🌏
Lähde: OJS 2020/S 212-516056 (2020-10-27)

Ilmoitus tehdystä sopimuksesta (2021-01-18)
Kohde
Hankinnan laajuus
Lyhyt kuvaus:

For and on the behalf of the contracting entity University of Helsinki (hereinafter referred to as the Buyer), we invited tenders for: 1.1 Ultimate sensitivity LC-MS/MS System for the analysis of lipid mediators, especially the specialized pro-resolving mediators (SPMs) at very low concentration levels, and capable for both ultimate sensitivity MRM quantification and information-dependent acquisition of full MS/MS spectra with high intensity, both from single injection as per enclosed specifications. 1.2 Optional parts for the system (1.1) as per enclosed specifications (II.2.4). 1.3 Training for use and service. 1.3.1 Training on site in connection with the installation. 1.3.2 Additional training for software, setting applications and basic service (option). 1.4 Installation and acceptance test on site. 1.5 Appropriate spare parts for mass spectrometer for five years operation.

Hankinnan kokonaisarvo: 344 852 EUR 💰
Ilmoituksen metatiedot
Asiakirjatyyppi: Ilmoitus tehdystä sopimuksesta

Menettely
Tarjouksen tyyppi: Ei sovelleta

Hankintaviranomainen
Tunnistetiedot
Hankintaviranomaisen nimi: University of Helsinki
Yhteystiedot
Internetosoite: https://www.helsinki.fi/en 🌏

Viite
Päivämäärät
Lähetyspäivä: 2021-01-18 📅
Julkaisupäivä: 2021-01-22 📅
Tunnisteet
Ilmoituksen numero: 2021/S 015-031075
Viittaa ilmoitukseen: 2020/S 212-516056
EUVL-S-numero: 15

Kohde
Hankinnan laajuus
Lyhyt kuvaus:

For and on the behalf of the contracting entity University of Helsinki (hereinafter referred to as the Buyer), we invited tenders for:

1.1 Ultimate sensitivity LC-MS/MS System for the analysis of lipid mediators, especially the specialized pro-resolving mediators (SPMs) at very low concentration levels, and capable for both ultimate sensitivity MRM quantification and information-dependent acquisition of full MS/MS spectra with high intensity, both from single injection as per enclosed specifications.

1.2 Optional parts for the system (1.1) as per enclosed specifications (II.2.4).

1.3 Training for use and service.

1.3.1 Training on site in connection with the installation.

1.3.2 Additional training for software, setting applications and basic service (option).

1.4 Installation and acceptance test on site.

1.5 Appropriate spare parts for mass spectrometer for five years operation.

a) Simultaneous

(i) scheduled collection of ultimate sensitivity quantitative MRM (Multiple Reaction Monitoring) data (for lipid mediator quantification) and

b) Sensitive detection with (lower) limit of quantification (L)LOQ of 0.05 ‒ 1 ng/mL for different lipid mediator species, in general, and with (L)LOQ 0.1 ng/mL or limit of detection (LOD, in matrix) 0.1 pg for the SPMs (resolvins) RvD1 or RvD3, and RvE1 (or lower values). You are requested to attach to your tender as reference three (3) published peer-reviewed research articles confirming that this level of sensitivity has been achieved by researchers for the above-mentioned analytes with the offered MS/MS equipment or older models of the same equipment of the Supplier. By references evidenced ultimate detection sensitivity for the above mentioned resolvins, lower than the (L)LOQ 0.1 ng/mL or LOD (this latter in matrix) 0.1 pg is acknowledged when evaluating quality.

c) Fast switching between the negative and positive ion mode detection in single injection and one LC-MS/MS acquisition.

These minimum requirements (1a,b,c) rule out triple quadrupole mass spectrometers that do not also have the ion trapping capabilities, required for the ultimate sensitivity SPM detection and high-quality full scan product ion MS/MS spectra. Possibility for true MS3 (i.e. MS/MS/MS) and MRM3 scanning is regarded beneficial when evaluating quality.

UHPLC quality assessment criteria are listed in Other terms and conditions.

Vaihtoehtojen kuvaus:

Optional parts for the system (1.1) as per enclosed specifications (II.2.4). Additional

Training for software, setting applications and basic service (option).

Menettely
Myöntämisperusteet
Laatukriteeri (nimi): Quality, the mass spectrometer (subdivided)
Laatukriteeri (painotus): 55
Laatukriteeri (nimi): Quality, UHPLC (subdivided)
Laatukriteeri (painotus): 10
Laatukriteeri (nimi): Quality, delivery time
Laatukriteeri (painotus): 5
Laatukriteeri (nimi): Quality, after-sales service and technical support
Hinta (painotus): 25

Sopimuksen tekeminen
Sopimuksen tekemispäivä: 2020-12-18 📅
Nimi: A B Sciex Oy
Kansallinen rekisterinumero: FI22883422
Postiosoite: c o Danaher Finland Oy, Biolinja 12
Postitoimipaikka: Turku
Postinumero: 20750
Maa: Suomi 🇫🇮
Manner-Suomi 🏙️
Hankinnan kokonaisarvo: 344 852 EUR 💰
Tietoa tarjouskilpailuista
Saatujen tarjousten määrä: 1
Lähde: OJS 2021/S 015-031075 (2021-01-18)

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